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Overactive Thyroid - Hyperthyroidism Disease - Symptoms, Causes and Complications Pace Hospitals Hyperthyroidism meaning Hyperthyroid disease (overactive thyroid) is a condition when the thyroid gland (butterfly-shaped gland in the front of the neck) creates and releases more thyroid hormones (triiodothyronine (T3) and tetraiodothyronine or thyroxine (T4) into the blood stream than the body needs